Linked Life Data

6468399

Source:http://linkedlifedata.com/resource/pubmed/id/6468399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-10-24
pubmed:abstractText
Recent reports in the literature of solid-state 13C nuclear magnetic resonance (NMR) spectra of crystalline L-alanine [Naito, A., Ganapathy, S., Akasaka, K., and McDonnell, C. A. (1981) J. Chem. Phys. 74, 3190-3197] and L-leucine [Frey, M. H. and Opella, S. J. (1980) J. Chem. Soc. Chem. Commun., 474-475], recorded with cross-polarization and magic-angle spinning (CP-MAS), show downfield resonance shifts of several parts per million in their side-chain methyl groups, relative to their resonance positions in aqueous solution. Similar findings are reported here for crystalline aliphatic amino acids and L-alanine peptides, including tetra(L-alanine), which show similar, specific downfield shifts in their side-chain methyl resonances. Coupled with X-ray crystallographic data of these compounds, and previous gas and solution-phase 13C NMR studies, the CP-MAS 13C NMR data indicate that these downfield shifts are a result of van der Waals' interactions. This group have reported similar van der Waals' induced shifts of the same magnitude for 13C resonances of the side-chain methyl groups of 13C-enriched tetra(L-alanine) upon binding to high-affinity Fab' fragments of heterogeneous sheep anti-[poly(L-alanine)] antibodies in aqueous solution [Geller, S., Wei, S. C., Shkuda, G. K., Marcus, D. M., and Brewer, C. F. (1980) Biochemistry 19, 3614-3623]. The above findings show that van der Waals' induced 13C NMR shifts of similar magnitudes can be detected in specific antibody-hapten complexes and the side chains of crystalline aliphatic amino acids and peptides. The results also indicate that water possesses relatively little attractive van der Waals' interactions with aliphatic molecules.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2956
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
van der Waals' induced 13C NMR shifts in crystalline amino acids and peptides.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.