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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1984-10-22
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pubmed:abstractText |
Peripheral blood lymphocytes were isolated at room temperature in a low sodium medium in 17 normotensive control subjects (NC) and 13 patients with essential hypertension (EHP). Lymphocyte sodium content was not significantly different between NC and EHP (3.1 +/- 0.5, n = 11, and 3.6 +/- 0.5, n = 10, respectively; means +/- SEM). The effect of frusemide on the ouabain-resistant rate constant of sodium efflux (KNao) from these lymphocytes into a sodium-free medium was measured. The frusemide-sensitive efflux rate constant was 75 +/- mus (n = 17) in controls and significantly lower in EHP (32 +/- 7 mus, n = 13, P less than 0.001). In human lymphocytes there is a ouabain-resistant, frusemide-sensitive fraction of sodium efflux into a sodium-free medium; this fraction may be reasonably attributed to a sodium-potassium cotransport system. This sodium transport pathway seems to be reduced in lymphocytes from EHP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0143-5221
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
407-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6467842-Adult,
pubmed-meshheading:6467842-Biological Transport, Active,
pubmed-meshheading:6467842-Female,
pubmed-meshheading:6467842-Furosemide,
pubmed-meshheading:6467842-Humans,
pubmed-meshheading:6467842-Hypertension,
pubmed-meshheading:6467842-Lymphocytes,
pubmed-meshheading:6467842-Male,
pubmed-meshheading:6467842-Ouabain,
pubmed-meshheading:6467842-Sodium
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pubmed:year |
1984
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pubmed:articleTitle |
Ouabain-resistant, frusemide-sensitive sodium efflux in human lymphocytes: a comparison of normotensive and hypertensive subjects.
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pubmed:publicationType |
Journal Article,
In Vitro
|