Linked Life Data

6467654

Source:http://linkedlifedata.com/resource/pubmed/id/6467654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-10-3
pubmed:abstractText
To test the hypothesis that parental aneuploidy, particularly involving sex chromosomes, indicates an increased risk of meiotic nondisjunction, we analyzed chromosome numbers from 283 parents who had had 2 or more spontaneous abortions and, if they had children, no abnormal offspring. A sample of 15 lymphocyte metaphases was examined per individual for a total of 4,245 metaphases. Two or more cells with the same abnormal chromosome complement were found in 19 individuals: 4 males with a minor number of 45,X cells and 15 females with minor numbers of 45,X and/or 47,XXX cells (p less than 0.001). The most logical explanation is that mitosis may, in part, reflect meiosis. This group of parents appears predisposed to chromosome errors in meiosis leading to recurrent spontaneous abortion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0009-9163
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Aneuploidy in recurrent spontaneous aborters: the tendency to parental nondisjunction.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't