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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-9-28
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pubmed:abstractText |
Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered daily for 5 days via a hepatic artery catheter to each of six patients with metastatic liver cancer. Transient but life-threatening toxicity principally involving the nervous and gastrointestinal systems occurred in five of them. Future investigation of hepatic intra-arterial infusion of vincristine should be based on dose-schedules other than that employed in the current trial.
|
pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
13
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
120-2
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6467495-Adult,
pubmed-meshheading:6467495-Aged,
pubmed-meshheading:6467495-Female,
pubmed-meshheading:6467495-Hepatic Artery,
pubmed-meshheading:6467495-Humans,
pubmed-meshheading:6467495-Infusions, Intra-Arterial,
pubmed-meshheading:6467495-Liver Neoplasms,
pubmed-meshheading:6467495-Male,
pubmed-meshheading:6467495-Middle Aged,
pubmed-meshheading:6467495-Vincristine
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pubmed:year |
1984
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pubmed:articleTitle |
Hepatic intra-arterial infusion of vincristine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|