Linked Life Data

6467209

Source:http://linkedlifedata.com/resource/pubmed/id/6467209

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1984-10-25
pubmed:abstractText
Cell survival, cell morphology, rate of protein synthesis, and recovery of protein synthesis have been investigated in two continuously growing rat hepatoma cell lines, namely, Reuber H35 and HTC, and rat hepatocytes in primary culture after exposure at temperatures between 37 and 44 degrees. H35 and HTC cells heated under identical culture conditions and at similar cell densities showed a remarkable difference in thermal sensitivity. For the continuously growing cell lines, the thermosensitivity of survival is reflected by thermally induced morphological alterations and the rate of recovery of protein synthesis but not by the thermally induced initial changes in protein synthesis. With the use of time-lapse cinematography, application of morphological criteria, and determination of the recovery of protein synthesis, the relative heat sensitivity of hepatocytes was evaluated as less than that of H35 cells but comparable to that of HTC cells. Therefore, it appears that hepatoma cell lines originating from the same tissue possess different heat sensitivities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4507-16
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Comparative studies of heat sensitivity of several rat hepatoma cell lines and hepatocytes in primary culture.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't