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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-4
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pubmed:dateCreated |
1984-8-24
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pubmed:abstractText |
A model is proposed for the early evolution of the coding mechanism. A primordial RNA embodies the functions of today's nucleic acids in a single molecule. The molecule is generated by successive rounds of self-priming and -templating. After proximity is assured by enclosure in a cell, the functions can be partitioned among more efficient specialized molecules. The prediction of sequence homologies in later forms prompted a search for matches between t- and r-RNAs. These are described. Their distributions offer clues to their origins. The existance of overlapping homologies indicates an approach to the reconstruction of an ancestral molecule.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0302-1688
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
571-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:6462693-Base Sequence,
pubmed-meshheading:6462693-Biological Evolution,
pubmed-meshheading:6462693-Genetic Code,
pubmed-meshheading:6462693-Models, Genetic,
pubmed-meshheading:6462693-Nucleic Acid Conformation,
pubmed-meshheading:6462693-RNA, Ribosomal,
pubmed-meshheading:6462693-RNA, Transfer
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pubmed:year |
1984
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pubmed:articleTitle |
tRNA-rRNA sequence homologies: a model for the origin of a common ancestral molecule, and prospects for its reconstruction.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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