Linked Life Data

6461918

Source:http://linkedlifedata.com/resource/pubmed/id/6461918

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-6-21
pubmed:abstractText
Concanavalin A (Con A) stimulation of T lymphocytes for 48 h induced a dose-dependent increase in the percentage of T gamma cells, and proliferation of these cells was dependent on pre-existing T gamma cells. Con A stimulation also induced a dose-dependent increase in suppressor cell activity as measured in a Con A/mixed lymphocyte culture assay. Removal of T gamma cells before stimulation with Con A did not influence suppressor cell activity, whereas depletion of T gamma cells after Con A stimulation significantly reduced the suppression. Treatment of T lymphocytes with monoclonal anti-HLA-DR antibodies and complement significantly increased the percentage of T gamma cells and also increased the suppressor cell activity, both when the cells were treated before and when they were treated after Con A stimulation. Similarly, increased suppressor cell activity was also seen when T mu cells were removed. The results indicate that Con-A-induced suppressor cells are recruited from both T gamma and T non-gamma cells and also suggest that most of the Con-A-induced suppressor cell activity is exerted by HLA-DR-negative cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Concanavalin A induces suppressor cell activity in both T gamma and T non-gamma cells: most of the suppressor cells do not carry HLA-DR antigens.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't