Linked Life Data

6461259

Source:http://linkedlifedata.com/resource/pubmed/id/6461259

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-5-27
pubmed:abstractText
Thyroidal trophic effects on slow-twitch skeletal muscle properties were compared in normally innervated and denervated soleus of rats maintained at different thyroid states. Hypothyroidism caused fast to slow changes in fiber type composition (99% decrease in proportion of type II fibers), ATPase activities (down 20-30%), myosin light chain pattern (54% less fast light chains), calcium uptake by SR (down 60%), LDH activity (down 11%), and isozyme pattern (9% decrease in M-subunits). Changes of similar magnitude but opposite in direction were induced by thyrotoxicosis. Denervations reversed, to varying degrees, the fast to slow transformations observed in hypothyroidism. However the slow to fast changes found in hyperthyroidism were facilitated rather than inhibited by denervation. These latter results clearly show that the hormone effect can be elicited in the absence of motor innervation. Furthermore, denervation alone caused slow to fast changes in euthyroid muscles. From these results, it is proposed that denervation and dysthyreosis alter muscle properties by independent mechanisms. Our data favor a direct action of thyroid hormone over a neurally mediated mechanism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
242
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R401-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Evidence for a direct action of thyroid hormone in specifying muscle properties.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't