Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1982-4-22
|
pubmed:abstractText |
Daily injection of human serum albumin into mice genetically selected to produce low-affinity antibody to protein antigens resulted in a more severe antigen-antibody-complex-induced glomerulonephritis than in mice producing high-affinity antibody. The low-affinity mice had higher levels of circulating antigen-antibody complexes, greater impairment of renal function and reduced reticuloendothelial clearance of 125I-PVP compared to high-affinity mice. Electron microscopy of glomeruli revealed the presence of subepithelial electron-dense deposits in low-affinity mice and predominantly subendothelial-mesangial deposits in high-affinity mice which corresponded to the predominantly capillary staining in low-affinity mice and mesangial staining in high-affinity mice by immunofluorescence. Auto-radiography of electron-microscopy sections demonstrated the presence of antigen in the electron-dense deposits, indicating that these deposits indeed contained antigen-antigen complexes.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0007-1021
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
62
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
614-22
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6459798-Animals,
pubmed-meshheading:6459798-Antibody Affinity,
pubmed-meshheading:6459798-Antigen-Antibody Complex,
pubmed-meshheading:6459798-Chronic Disease,
pubmed-meshheading:6459798-Fluorescent Antibody Technique,
pubmed-meshheading:6459798-Glomerulonephritis,
pubmed-meshheading:6459798-Immune Complex Diseases,
pubmed-meshheading:6459798-Kidney,
pubmed-meshheading:6459798-Kidney Glomerulus,
pubmed-meshheading:6459798-Mice,
pubmed-meshheading:6459798-Mice, Inbred Strains,
pubmed-meshheading:6459798-Microscopy, Electron,
pubmed-meshheading:6459798-Mononuclear Phagocyte System
|
pubmed:year |
1981
|
pubmed:articleTitle |
Chronic antigen-antibody-complex glomerulonephritis in mice.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|