Linked Life Data

6455061

Source:http://linkedlifedata.com/resource/pubmed/id/6455061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-9-15
pubmed:abstractText
Surface markers, terminal transferase, cytochemical staining, and function of peripheral blood lymphocytes were examined in nine patients with T-cell lymphoproliferative disease. Anti-T-cell antiserum proved useful in characterizing the phenotypes of the abnormal cells when only a minority of the abnormal cells formed E-rosettes. Anti-B-cell antiserum was consistently unreactive with the abnormal cells. Terminal transferase was elevated in T-cell ALL but low in T-cell CLL, lymphoma-leukemia, or Sézary syndrome. Lymphocyte proliferative response to nonspecific mitogens was generally depressed as was the response to allogeneic cells. The cells also failed to stimulate in mixed lymphocyte culture, implying a lack of Ia antigens on their surface. Acid phosphatase stain was positive in three patients tested. Peroxidase and esterase stains were negative, whereas PAS was positive in five of eight patients tested. Prognosis in general, regardless of the clinical picture, (ie, acute, chronic, or lymphoma-leukemia), was poor with seven of the nine patients dying within 14 months of diagnosis. Therefore, the use of anti-T-cell antisera and the E-rosette surface marker should be used to characterize the phenotype of the malignant cells in lymphoproliferative disease to enable more vigorous treatment of those that are of T-cell origin and that therefore carry a poor prognosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-8609
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-30
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The immunological and cytochemical characterization of T-cell lymphoproliferative diseases.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't