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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1981-9-15
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pubmed:abstractText |
Concanavalin A (Con-A)-induced suppressor T cells were found to respond to T cell growth factor (TCGF) by proliferation. TCGF abrogated the suppressor activity exerted by these cells on phytohemagglutinin (PHA)- and alloantigen- induced lymphocyte proliferation and on pokeweed mitogen (PWM)-driven immunoglobulin secretion. The Con-A-activated suppressor T cells absorbed the TCGF activity, preincubation of these active suppressor cells with TCGF abolished their suppressor activity and addition of increasing numbers of Con-A-activated T cells reverted the abrogator,/ effect of TCGF. Altogether, these findings suggest that Con-A-induced suppressor T cells exert their function by decreasing the available levels of TCGF. Cyclosporin-A (CYA), which is known to inhibit the expression of receptors for TCGF on T cells, also inhibited the suppressor activity as determined in both indicator systems, namely PHA- or alloantigen-induced DNA synthesis and PWM-induced immunoglobulin synthesis. CYA made Con-A-treated T cells unresponsive to TCGF and unable to absorb the growth factor, supporting the notion that CYA inhibits the expression of TCGF receptors on T cells, a mechanism by which this drug seems to abrogate Con-A-induced suppressor T cell function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-131175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-181845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-450142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-6447710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-6966190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-6966298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6454746-789096
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
153
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1360-5
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:6454746-Concanavalin A,
pubmed-meshheading:6454746-Cyclosporins,
pubmed-meshheading:6454746-Humans,
pubmed-meshheading:6454746-Interleukin-2,
pubmed-meshheading:6454746-Lymphokines,
pubmed-meshheading:6454746-Peptides, Cyclic,
pubmed-meshheading:6454746-T-Lymphocytes,
pubmed-meshheading:6454746-T-Lymphocytes, Regulatory
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pubmed:year |
1981
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pubmed:articleTitle |
T cell growth factor abrogates concanavalin A-induced suppressor cell function.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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