| pubmed-article:6453583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6453583 | lifeskim:mentions | umls-concept:C0017973 | lld:lifeskim |
| pubmed-article:6453583 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:6453583 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:6453583 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6453583 | pubmed:dateCreated | 1981-7-20 | lld:pubmed |
| pubmed-article:6453583 | pubmed:abstractText | Heparan sulphate, heparin and dermatan sulphate were hydrolysed in 0.5M-H2SO4 at 100 degrees C. At intervals portions of the hydrolysate were removed and treated with HNO2 at pH 4.0 to cleave the glycosidic bonds of the N-unsubstituted hexosamine residues and to convert both free and combined hexosamines into anhydrohexoses. These hydrolysis/deamination mixtures were reduced with NaB3H4 and analysed by radiochromatography for alpha-L-iduronosylanhydrohexose, beta-D-glucuronosylanhydrohexose, and the free uronic acids and anhydrohexose. These data gave a kinetic profile of the cleavage of the alpha-L-iduronosyl and the beta-D-glucuronosyl bonds in these glycosaminoglycans. The beta-D-glucuronosyl bonds showed the expected resistance to acid hydrolysis, but the alpha-L-iduronosyl bonds were found to be as labile to acid as some neutral sugar glycosides. This unusual lability of alpha-D-iduronosyl-anhydromannitol and beta-D-glucuronosylanhydromannitol. The procedures used to follow the kinetics of glycosaminoglycan hydrolysis can also be sued to obtain quantitative analyses of L-iduronic acid, D-glucuronic acid and hexosamine in these polymers. | lld:pubmed |
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| pubmed-article:6453583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6453583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6453583 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6453583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6453583 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6453583 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6453583 | pubmed:author | pubmed-author:ConnorE LEL | lld:pubmed |
| pubmed-article:6453583 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6453583 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6453583 | pubmed:volume | 191 | lld:pubmed |
| pubmed-article:6453583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6453583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6453583 | pubmed:pagination | 355-63 | lld:pubmed |
| pubmed-article:6453583 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:6453583 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6453583 | pubmed:articleTitle | The acid lability of the glycosidic bonds of L-iduronic acid residues in glycosaminoglycans. | lld:pubmed |
| pubmed-article:6453583 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6453583 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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