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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1981-7-20
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pubmed:abstractText |
Pretreatment of BALB/c mice with Corynebacterium parvum inhibited the induction of tolerance to the contact sensitizing agent 2,4-dinitrofluorobenzene induced by intravenous injection of DNBSO3. The suppressive effect on tolerance induction has further been analyzed by adoptive transfer experiments. Injection of C. parvum intraperitoneally (0.7-2.8 mg/mouse) before injection of the tolergen inhibited the generation of T-suppressor cells as shown by transfer of spleen cells from the tolerized donor to naive recipients. Pretreatment of the recipients of the suppressor T-cells from tolerized animals with C. parvum also inhibited the function of these cells in the recipient animals. Time-kinetic experiments suggested that more than one mechanism appeared to be responsible for the tolerance induced by DNBSO3; C. parvum (probably via activated macrophages) suppressed tolerance which is mediated by T-suppressor lymphocytes. These results suggest that T-suppressor lymphocytes may--similarly as T-helper cells--be modulated by an activated monocytic-phagocytic system.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
|
pubmed:issn |
0022-202X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
76
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
396-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6453168-Adjuvants, Immunologic,
pubmed-meshheading:6453168-Animals,
pubmed-meshheading:6453168-Dermatitis, Contact,
pubmed-meshheading:6453168-Dinitrofluorobenzene,
pubmed-meshheading:6453168-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6453168-Immune Tolerance,
pubmed-meshheading:6453168-Mice,
pubmed-meshheading:6453168-Propionibacterium acnes,
pubmed-meshheading:6453168-T-Lymphocytes, Regulatory
|
pubmed:year |
1981
|
pubmed:articleTitle |
Modulation of suppressor mechanisms in allergic contact dermatitis: 2. Inhibition of suppressor T-lymphocytes by Corynebacterium parvum.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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