Linked Life Data

6452529

Source:http://linkedlifedata.com/resource/pubmed/id/6452529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-6-25
pubmed:abstractText
Bactericidal capacity was investigated to delineate the impairment of phagocytic function. Fourteen individuals with Down syndrome and fifteen matched institutionalised controls were studied. A non-matched comparison normal group was also evaluated, representing a non-institutionalised young adult population. Neutrophil bactericidal capacity was impaired in institutionalised subjects, the defect being most apparent in Down syndrome. Monocyte bactericidal capacity was identical in institutionalised and non-institutionalised subjects. Humoral functions revealed no differences. Neutrophil phagocytosis was diminished in institutionalised individuals, Down syndrome subjects being the least effective. Monocytes had normal phagocytosis, but opsonisation was defective in both the Down syndrome and matched institutionalised groups. Neutrophils were more efficient at phagocytosis than monocytes. No physiologically significant differences were noted in neutrophil or monocyte intracellular killing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-264X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24 Pt 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Phagocytic function in Down syndrome--II. Bactericidal activity and phagocytosis.
pubmed:publicationType
Journal Article, Comparative Study