Linked Life Data

6449766

Source:http://linkedlifedata.com/resource/pubmed/id/6449766

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-2-26
pubmed:abstractText
The recovery of T-cell immunocompetence in irradiated mice repopulated with syngeneic bone marrow cells has been studied. Both thymocytes and spleen cells from irradiated recipients were tested for Concanavalin A mitogen responsiveness, mixed lymphocyte reactivity, generation of trinitrophenyl-hapten-modified self cytotoxicity and helper cell carrier function. Responsiveness in the thymus reaches peak levels between 3-5 wk after marrow transfer, while splenic reactivity peaks at least 2-3 wk later, presumably a reflection of emigration from the thymus to peripheral lymphoid organs. Most T-cell functions reappeared at approximately the same time, though Con A responsiveness appeared first and helper activity for indirect IgG formation last. Since we have previously demonstrated that helper cell precursors in the marrow can be rendered tolerant, these studies will now allow definition of specificity in other T-cell subsets.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0165-6090
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-74
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Functional differentiation of T-cell precursors. II. Recovery of immunocompetence in lethally irradiated bone marrow reconstituted mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.