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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1981-2-26
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pubmed:abstractText |
A soluble suppressor factor (SSF) has been demonstrated in the supernatant of normal human peripheral blood lymphocyte cultures that exhibits suppressive activity toward the proliferative response of normal lymphocytes to concanavalin A or alloantigens in mixed lymphocyte culture (MLC) or toward pokeweed mitogen-stimulated immunoglobulin synthesis and secretion in vitro. Suppression of the proliferative response in MLC reached maximal levels when added SSF-containing supernatant approximated 20% by volume of the culture medium. Suppression in the MLC was found to act at the proliferative stage. SSF acts independently of cytotoxicity and is stable at 56 degrees C for 30 min but is inactivated at higher temperatures. Addition of SSF to the MLC as late as day 4 after initiation of the culture results in suppression of transformation. This factor(s) may regulate the magnitude of several immune responses in humans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-1081931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-123261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-131175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-140197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-156215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-266731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-302273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-305449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-308038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-312832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-325145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-355117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-365711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-4149590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-4253530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-4272725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-4439452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-4541122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-6767779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-794409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6449702-864254
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6096-100
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6449702-Antibody Formation,
pubmed-meshheading:6449702-Cells, Cultured,
pubmed-meshheading:6449702-Cytotoxicity, Immunologic,
pubmed-meshheading:6449702-Humans,
pubmed-meshheading:6449702-Immune Tolerance,
pubmed-meshheading:6449702-Lymphocyte Activation,
pubmed-meshheading:6449702-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6449702-Lymphocytes,
pubmed-meshheading:6449702-Lymphokines,
pubmed-meshheading:6449702-T-Lymphocytes, Regulatory
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pubmed:year |
1980
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pubmed:articleTitle |
A human soluble suppressor factor affecting lymphocyte responses in vitro.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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