Linked Life Data

6448350

Source:http://linkedlifedata.com/resource/pubmed/id/6448350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5780
pubmed:dateCreated
1980-12-18
pubmed:abstractText
Recent studies have suggested that actomyosin threads may provide a useful model for studying the properties of contractile systems. The development of highly sensitive positional feedback transducers has enabled the properties of these threads to be measured reproducibly. Potential applications include such systems as ventricle, smooth muscle and non-muscle preparations, from which it is difficult to obtain suitable fibres for mechanical studies. In addition, studies with chemically modified myosins may provide new insights into the relationships between the biochemical and mechanical events in the cross-bridge cycle. However, there are indications that the mechanical properties of actomyosin threads differ from those of intact fibres in several important respects. For example, contraction velocity is proportional to isometric tension in threads, but is independent of filament density in intact fibres. We have now determined the force-velocity characteristics of actomyosin threads prepared from muscles with known differences in their physiological contraction velocities. No direct relationships could be found between the velocity characteristics of the threads and those of intact muscle. We conclude that the measured velocities of threads reflect properties of the actomyosins other than cross-bridge cycling times, thus severely limiting the usefulness of this technique for comparative purposes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
287
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
338-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Limitations in the use of actomyosin threads as model contractile systems.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't