| pubmed-article:6447636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6447636 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:6447636 | lifeskim:mentions | umls-concept:C0229525 | lld:lifeskim |
| pubmed-article:6447636 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:6447636 | lifeskim:mentions | umls-concept:C0006772 | lld:lifeskim |
| pubmed-article:6447636 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:6447636 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:6447636 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6447636 | pubmed:dateCreated | 1980-11-25 | lld:pubmed |
| pubmed-article:6447636 | pubmed:abstractText | Calmodulin interaction with Ca2+ may present a receptor mechanism analogous to the association of steroid hormones with cytoplasmic receptor proteins. In the systems examined to date, neither calmodulin nor Ca2+ alone have stimulatory effects. We have attempted to illustrate the similarities between the regulation of cellular events by Ca2+-calmodulin and the cyclic nucleotide system. If a general mechanism for calmodulin can be predicted it is to activate various enzymes to phosphorylate target proteins in a Ca2+-dependent manner. It is also of interest to point out the coorindate regulation of protein phosphorylation by Ca2+ and cAMP. Calmodulin can be considered to be involved in both types of reactions. This Ca2+-receptor not only activates Ca2+-dependent protein kinases directly but also plays an indirect role in cAMP-dependent phosphorylation by participating in the regulation of the intracellular steady-state levels of cAMP. The importance of calmodulin as a Ca2+-receptor and as a modulator of hormone action and endocrine cells illustrates the pleiotypic nature of this protein in both cellular and molecular aspects of endocrinology. | lld:pubmed |
| pubmed-article:6447636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6447636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6447636 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6447636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6447636 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6447636 | pubmed:issn | 0303-7207 | lld:pubmed |
| pubmed-article:6447636 | pubmed:author | pubmed-author:MeansA RAR | lld:pubmed |
| pubmed-article:6447636 | pubmed:author | pubmed-author:DedmanJ RJR | lld:pubmed |
| pubmed-article:6447636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6447636 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:6447636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6447636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6447636 | pubmed:pagination | 215-27 | lld:pubmed |
| pubmed-article:6447636 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:6447636 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6447636 | pubmed:articleTitle | Calmodulin in endocrine cells and its multiple roles in hormone action. | lld:pubmed |
| pubmed-article:6447636 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6447636 | pubmed:publicationType | Review | lld:pubmed |
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