Linked Life Data

6447636

Source:http://linkedlifedata.com/resource/pubmed/id/6447636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-11-25
pubmed:abstractText
Calmodulin interaction with Ca2+ may present a receptor mechanism analogous to the association of steroid hormones with cytoplasmic receptor proteins. In the systems examined to date, neither calmodulin nor Ca2+ alone have stimulatory effects. We have attempted to illustrate the similarities between the regulation of cellular events by Ca2+-calmodulin and the cyclic nucleotide system. If a general mechanism for calmodulin can be predicted it is to activate various enzymes to phosphorylate target proteins in a Ca2+-dependent manner. It is also of interest to point out the coorindate regulation of protein phosphorylation by Ca2+ and cAMP. Calmodulin can be considered to be involved in both types of reactions. This Ca2+-receptor not only activates Ca2+-dependent protein kinases directly but also plays an indirect role in cAMP-dependent phosphorylation by participating in the regulation of the intracellular steady-state levels of cAMP. The importance of calmodulin as a Ca2+-receptor and as a modulator of hormone action and endocrine cells illustrates the pleiotypic nature of this protein in both cellular and molecular aspects of endocrinology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-27
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Calmodulin in endocrine cells and its multiple roles in hormone action.
pubmed:publicationType
Journal Article, Review