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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5773
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pubmed:dateCreated |
1980-10-27
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pubmed:abstractText |
Cyclosporin A (CS-A) is an unusual endecapeptide isolated from the fungi Cylindrocarpon lucidum Booth and Trichoderma polysporum. It is a potent immunosuppressive drug that prevents rejection of kidney and heart allografts whilst having a low myelotoxicity. Its mode of action is still unclear but its main target appears to be the T lymphocyte. The mixed lymphocyte reaction (MLR) and cell-mediated lymphocytoxicity (CML) used here are generally regarded as in vitro correlates of allograft rejection. Our data show that CS-A is a powerful inhibitor of MLR reactivity, regardless of whether the cells were obtained from normal or presensitized donors; that the CML of lymph node cells is likewise totally inhibited if the drug is added early during cell culture; and that, by contrast, the cytotoxic response of spleen cells from presensitized but not from normal mice is only partially inhibited, even with a tenfold increase in dose. It is therefore suggested that there exists a population of cytotoxic spleen cells that is relatively resistant to the action of this drug.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-11
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6447256-Animals,
pubmed-meshheading:6447256-Cells, Cultured,
pubmed-meshheading:6447256-Cyclosporins,
pubmed-meshheading:6447256-Cytotoxicity, Immunologic,
pubmed-meshheading:6447256-Dose-Response Relationship, Drug,
pubmed-meshheading:6447256-Immune Tolerance,
pubmed-meshheading:6447256-Lymphocyte Activation,
pubmed-meshheading:6447256-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6447256-Mice,
pubmed-meshheading:6447256-Peptides, Cyclic,
pubmed-meshheading:6447256-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
Suppression of in vitro lymphocyte reactivity by cyclosporin A: existence of a population of drug-resistant cytotoxic lymphocytes.
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pubmed:publicationType |
Journal Article
|