Linked Life Data

6447162

Source:http://linkedlifedata.com/resource/pubmed/id/6447162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-10-24
pubmed:abstractText
The metabolism of a tracer of [3H]dehydroisoandrosterone sulfate ([3H]DHAS) was studied in five normal women and six normal men. Two major sex differences were found. 1) The total urinary recovery of radioactivity was considerably greater in women (73 +/- 5.5% of the dose vs. 51 +/- 3.5; P less than 0.01), principally due to higher excretion of nonglucuronide, nonsulfate conjugates (35 +/- 2.2% of the dose vs. 21 +/- 3.9%; P less than 0.025). This finding is analogous to the sex difference in estradiol metabolism we have reported and is hypothesized to represent diversion of excretion of these conjugates in women from the biliary to the urinary excretion route because of the known lower biliary excretory capacity of women, which is a consequence of their higher estrogen levels. 2) The recovery of androsterone and etiocholanolone was considerably higher in the women (15.4 +/- 1.4% of the dose vs. 10 +/- 1.8%; P less than 0.05). Since conversion of DHAS to etiocholanolone and androsterone in vivo entails prior cleavage of DHAS to DHA, this sex difference in the recovery of androsterone and etiocholanolone is interpreted to mean that DHAS leads to DHA cleavage is considerably greater in women than in men. It is predicted that the plasma DHA to DHAS ratio should be substantially greater in women then in men.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
334-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Sex difference in the metabolism of dehydroisoandrosterone sulfate.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.