Linked Life Data

6445443

Source:http://linkedlifedata.com/resource/pubmed/id/6445443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-7-26
pubmed:abstractText
Two mechanisms have been proposed to explain the secretory action of laxative compounds in the intestine: 1. increase of the intracellular amount of cyclic adenosine monophosphate due to stimulation of the adenylate cyclase system and 2. inhibition of intestinal transfer processes, in particular the Na,K-ATPase activated sodium absorption. In a set of in vivo and in vitro experiments in rat colon it could be demonstrated that dihydroxy bile acids (deoxycholate) and diphenolic laxatives (oxyphenisatin) enhance the hydraulic permeability of the mucosal tissue. The permeability changes take place--and there is good experimental evidence--at the zonulae occludentes which bind the epithelial cells together at their luminal borders. Due to laxative action the hydraulic permeability of the colonic mucosa increases to such an extent that according to the Starling forces the normal subepithelial hydrostatic pressure is a sufficient driving force to reverse net sodium, chloride, and water absorption into net secretion. A new concept of "intestinal filtration as a consequence of increased mucosal hydraulic permeability" is proposed to explain the laxative action of deoxycholate and oxyphenisatin in the colon. The question whether inhibition of Na,K-ATPase activity, cyclic AMP-mediated secretion or increased hydraulic permeability of the colonic mucosa are causatively linked to and quantitatively meaningful in intestinal secretion remains open.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0023-2173
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-78
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Intestinal filtration as a consequence of increased mucosal hydraulic permeability. A new concept for laxative action.
pubmed:publicationType
Journal Article