| pubmed-article:6445398 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C2355612 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C0038858 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6445398 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:6445398 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6445398 | pubmed:dateCreated | 1980-7-22 | lld:pubmed |
| pubmed-article:6445398 | pubmed:abstractText | Administration of azobenzenearsonate (ABA)-coupled syngeneic spleen cells intravenously to A/J mice leads to the generation of suppressor T cells (Ts1) which exhibit specific binding to ABA-bovine serum albumin (BSA)-coated dishes. These Ts1 share idiotypic determinants with the major cross-reactive idiotype (CRI) of the anti-ABA antibodies of A/J mice, and also produce a soluble suppressor factor (TsF) bearing CRI and I-J subregion-coded determinants. Injection of this TsF into naive A/J mice elicits a second set of specific suppressor cells (Ts2) which are not lysed by anti-CRI antibody plus C, and which do not bind to ABA-BSA-coated dishes. However, in contrast with Ts1, these Ts2 do bind to plates bearing CRI+ anti-ABA immunoglobulin. Thus, Ts2 exhibit anti-idiotypic specificity. These data indicate that antigen elicits the production of a soluble T cell product bearing both variable portion of the Ig heavy chain (VH) and I-J subregion-coded determinants which serves to communicate between T cell subsets to establish an idiotype-anti-idiotype regulatory pathway. | lld:pubmed |
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| pubmed-article:6445398 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6445398 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6445398 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6445398 | pubmed:month | May | lld:pubmed |
| pubmed-article:6445398 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6445398 | pubmed:author | pubmed-author:BenacerrafBB | lld:pubmed |
| pubmed-article:6445398 | pubmed:author | pubmed-author:SyM SMS | lld:pubmed |
| pubmed-article:6445398 | pubmed:author | pubmed-author:GreeneM IMI | lld:pubmed |
| pubmed-article:6445398 | pubmed:author | pubmed-author:GermainR NRN | lld:pubmed |
| pubmed-article:6445398 | pubmed:author | pubmed-author:DietzM HMH | lld:pubmed |
| pubmed-article:6445398 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6445398 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6445398 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:6445398 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6445398 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6445398 | pubmed:pagination | 1183-95 | lld:pubmed |
| pubmed-article:6445398 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6445398 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6445398 | pubmed:articleTitle | Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors. | lld:pubmed |
| pubmed-article:6445398 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6445398 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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