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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1980-7-22
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pubmed:abstractText |
Administration of azobenzenearsonate (ABA)-coupled syngeneic spleen cells intravenously to A/J mice leads to the generation of suppressor T cells (Ts1) which exhibit specific binding to ABA-bovine serum albumin (BSA)-coated dishes. These Ts1 share idiotypic determinants with the major cross-reactive idiotype (CRI) of the anti-ABA antibodies of A/J mice, and also produce a soluble suppressor factor (TsF) bearing CRI and I-J subregion-coded determinants. Injection of this TsF into naive A/J mice elicits a second set of specific suppressor cells (Ts2) which are not lysed by anti-CRI antibody plus C, and which do not bind to ABA-BSA-coated dishes. However, in contrast with Ts1, these Ts2 do bind to plates bearing CRI+ anti-ABA immunoglobulin. Thus, Ts2 exhibit anti-idiotypic specificity. These data indicate that antigen elicits the production of a soluble T cell product bearing both variable portion of the Ig heavy chain (VH) and I-J subregion-coded determinants which serves to communicate between T cell subsets to establish an idiotype-anti-idiotype regulatory pathway.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-107261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-1085311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-109574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-1101468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-1254948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-15036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-302317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-303682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-312894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-325170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-4110016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-4598645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-56011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-6153672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-6445395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-68889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-6966320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-75231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-782637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-81235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-82578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-85681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-87484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-87487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-91111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-91657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6445398-92517
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1183-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6445398-Animals,
pubmed-meshheading:6445398-Antibodies, Anti-Idiotypic,
pubmed-meshheading:6445398-Antigens, Surface,
pubmed-meshheading:6445398-Complement System Proteins,
pubmed-meshheading:6445398-Cytotoxicity, Immunologic,
pubmed-meshheading:6445398-Female,
pubmed-meshheading:6445398-Hypersensitivity, Delayed,
pubmed-meshheading:6445398-Immunity, Cellular,
pubmed-meshheading:6445398-Immunoglobulin Idiotypes,
pubmed-meshheading:6445398-Isoantigens,
pubmed-meshheading:6445398-Lymphokines,
pubmed-meshheading:6445398-Major Histocompatibility Complex,
pubmed-meshheading:6445398-Mice,
pubmed-meshheading:6445398-Receptors, Immunologic,
pubmed-meshheading:6445398-T-Lymphocytes,
pubmed-meshheading:6445398-T-Lymphocytes, Regulatory
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pubmed:year |
1980
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pubmed:articleTitle |
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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