Linked Life Data

6442038

Source:http://linkedlifedata.com/resource/pubmed/id/6442038

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pubmed-article:6442038pubmed:abstractTextAs shown by means of Ouchterlony double immunodiffusion technique after induction with 3-methyl cholanthrene the antibodies towards cytochrome P-448 from rat liver tissue developed a clear-cut precipitation line with homologous antigen and interacted also with cytochrome P-448 from mice liver tissue although the precipitation was less distinct. Antibodies towards mice liver cytochrome P-448 reacted also with the rat liver cytochrome P-448 but less distinctly as compared with the mice cytochrome. At the same time, these antibodies inhibited similarly the benz(a)-pyrene-hydroxylase reaction, catalyzed by both mice and rat cytochromes P-448. Partial immunological identity appears to occur in the cytochromes studied. Role of total antigenic determinants in enzymatic reactions catalyzed by cytochrome P-448 is discussed.lld:pubmed
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pubmed-article:6442038pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:6442038pubmed:articleTitle[Immunological study of the identity of cytochrome P-448 in the mouse and rat liver after induction with 3-methylcholanthrene].lld:pubmed
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pubmed-article:6442038pubmed:publicationTypeEnglish Abstractlld:pubmed