Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-3-27
pubmed:abstractText
One hundred and thirty-six patients with neuroblastoma have been treated at our center from 1970 to 1982, using various combinations of surgery, radiation therapy, and chemotherapy. Choice of therapy was individualized but depended primarily on age and stage. The overall disease-free survival was 60% (minimum follow-up of one year). Patients with stage I disease and younger patients with stage II disease usually received less intensive therapy and fared extremely well (100% survival). Patients with stage III disease and older patients with stage II disease also did extremely well (survival of 85% and 90%, respectively). These patients may have benefited from intensive treatment with all three modalities. Patients under one year of age with stage IV neuroblastoma were treated with surgery and multiagent chemotherapy, and 92% (11/12) survived free of disease. Patients over one year old with stage IV disease represented the only group for which therapy was unsuccessful (10% survival). With combination approaches and with more effective multiagent chemotherapeutic regimens, a real impact on the survival of older stage II patients, stage III patients, and younger stage IV patients appears to have been made. However, older stage IV patients are rarely cured with conventional therapy, and better approaches will be needed for this group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0167-8140
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-200
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed-meshheading:6441972-Adolescent, pubmed-meshheading:6441972-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:6441972-Child, pubmed-meshheading:6441972-Child, Preschool, pubmed-meshheading:6441972-Cisplatin, pubmed-meshheading:6441972-Combined Modality Therapy, pubmed-meshheading:6441972-Cyclophosphamide, pubmed-meshheading:6441972-Dacarbazine, pubmed-meshheading:6441972-Doxorubicin, pubmed-meshheading:6441972-Drug Administration Schedule, pubmed-meshheading:6441972-Humans, pubmed-meshheading:6441972-Infant, pubmed-meshheading:6441972-Mechlorethamine, pubmed-meshheading:6441972-Mitomycin, pubmed-meshheading:6441972-Mitomycins, pubmed-meshheading:6441972-Neuroblastoma, pubmed-meshheading:6441972-Prognosis, pubmed-meshheading:6441972-Radiotherapy, High-Energy, pubmed-meshheading:6441972-Vincristine
pubmed:year
1984
pubmed:articleTitle
Improved survival in neuroblastoma using multimodality therapy.
pubmed:publicationType
Journal Article