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A new polyvalent Pseudomonas aeruginosa vaccine consisting of extracts of the 24 serotypes of the Lanyi typing scheme was developed and evaluated in mouse protection studies. The vaccine, mainly consisting of lipopolysaccharides and outer membrane proteins was protective in passive and active protection studies. A rabbit antiserum against the vaccine showed high protective capacity in the IgG-fraction and was protective against 3 out of 6 challenge strains in a leucopenic mouse model.
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