Linked Life Data

6441149

Source:http://linkedlifedata.com/resource/pubmed/id/6441149

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-3-19
pubmed:abstractText
Membrane potential and resistance were measured in isolated segments of mouse pancreas superfused in vitro using two intracellular microelectrodes. The acinar cells were stimulated by microionophoretic ACh application from an extracellular AChCl filled micropipette. The membrane depolarization and resistance reduction evoked by short pulses of ACh stimulation were abolished by treatment with A23187 containing Ca-free solution. The subsequent exposure of the A23187-treated tissue to a Ca or Sr containing solution restored the responses to short pulses of ACh. Addition of Ba, Co, or Mn instead of Ca had no such restorative effects. Mn or Co markedly suppressed the restorative effects of Ca or Sr. It is concluded that A23187 treatment causes depletion of intracellular Ca stores. The restorative effect of Ca or Sr indicates that short pulses of ACh stimulation evoke an increase in intracellular Ca or Sr concentration. Short pulses of ACh seem to release Ca from the stimulant-sensitive Ca pool and, in addition, to increase the membrane Ca permeability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
402
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of divalent cations on acetylcholine-evoked membrane potential in the ionophore A23187 treated mouse pancreas.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't