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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1985-2-11
|
| pubmed:abstractText |
Some kinetic Properties of beta-galactosidase in crude extracts of cultured fibroblasts obtained from patients with Morquio B disease, GM1-gangliosidosis and from the controls were compared. The main defect in Morquio B seems to be the lowering of enzyme affinity to the substrates, while in the case of GM1-gangliosidosis of infantile type 1 a dramatic decrease of Vmax value concomitant with normal KM value was observed. Based on these observations possible interpretations of the clinical picture are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0258-0357
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
301-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6439230-Fibroblasts,
pubmed-meshheading:6439230-Galactosidases,
pubmed-meshheading:6439230-Gangliosidoses,
pubmed-meshheading:6439230-Humans,
pubmed-meshheading:6439230-Hydrogen-Ion Concentration,
pubmed-meshheading:6439230-Kinetics,
pubmed-meshheading:6439230-Mucopolysaccharidoses,
pubmed-meshheading:6439230-beta-Galactosidase
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Kinetic properties of beta-galactosidase in Morquio B disease.
|
| pubmed:publicationType |
Journal Article
|