Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1978-6-17
|
| pubmed:abstractText |
A dose-dependent increase of paracetamol serum half-life (t1/2) was found after oral and intravenous application in rats and oral application in mice. The hepatotoxic effects of paracetamol were not correlated with this prolongation of t1/2. Dithiocarb protected rats against paracetamol liver damage but did not change paracetamol t1/2. Paracetamol t1/2 was not influenced either by a hepatotoxic dose of carbon tetrachloride. In conclusion, the dose-dependent prolongation of paracetamol serum half-life is not due to paracetamol-induced liver damage but merely the consequence of saturated elimination processes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0031-7012
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-8
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:643897-Acetaminophen,
pubmed-meshheading:643897-Administration, Oral,
pubmed-meshheading:643897-Animals,
pubmed-meshheading:643897-Carbon Tetrachloride Poisoning,
pubmed-meshheading:643897-Dose-Response Relationship, Drug,
pubmed-meshheading:643897-Drug-Induced Liver Injury,
pubmed-meshheading:643897-Half-Life,
pubmed-meshheading:643897-Injections, Intravenous,
pubmed-meshheading:643897-Liver,
pubmed-meshheading:643897-Male,
pubmed-meshheading:643897-Mice,
pubmed-meshheading:643897-Rats,
pubmed-meshheading:643897-Thiocarbamates
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Relations between hepatotoxicity and pharmacokinetics of paracetamol in rats and mice.
|
| pubmed:publicationType |
Journal Article
|