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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1985-1-14
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pubmed:abstractText |
A serratial protease with an apparent molecular weight of 56,000 (56K protease), which had been purified from the culture supernatant of a strain of Serratia marcescens isolated from a corneal lesion of a human eye [Matsumoto, K. et al. (1984) J. Bacteriol. 157, 225-232], greatly enhanced vascular permeability when injected into guinea pig skin. The 56K protease, which requires zinc ion for activity, was found to possess plasma kallikrein-like properties in vitro as judged by (i) preferential amidolysis of carbobenzoxy-Phe-Arg-4-methylcoumaryl-7-amide and Pro-Phe-Arg-4-methylcoumaryl-7-amide, which are known substrates for plasma kallikrein; (ii) release of kinin from high-molecular-weight kininogen; and (iii) prompt activation of Hageman factor followed by generation of kallikrein from plasma prekallikrein. These results suggest that the 56K protease enhances vascular permeability through activation of a Hageman factor-kallikrein-kinin pathway in vivo, and this molecular process appears to be a rational mechanism of enhancement of permeability and serratial pathogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-924X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
739-49
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pubmed:dateRevised |
2007-12-19
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pubmed:meshHeading |
pubmed-meshheading:6438075-Animals,
pubmed-meshheading:6438075-Bacterial Infections,
pubmed-meshheading:6438075-Blood Coagulation,
pubmed-meshheading:6438075-Corneal Diseases,
pubmed-meshheading:6438075-Enzyme Activation,
pubmed-meshheading:6438075-Factor XII,
pubmed-meshheading:6438075-Female,
pubmed-meshheading:6438075-Guinea Pigs,
pubmed-meshheading:6438075-Humans,
pubmed-meshheading:6438075-Immunodiffusion,
pubmed-meshheading:6438075-Kallikreins,
pubmed-meshheading:6438075-Kinetics,
pubmed-meshheading:6438075-Male,
pubmed-meshheading:6438075-Molecular Weight,
pubmed-meshheading:6438075-Peptide Hydrolases,
pubmed-meshheading:6438075-Prekallikrein,
pubmed-meshheading:6438075-Serratia marcescens,
pubmed-meshheading:6438075-Substrate Specificity
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pubmed:year |
1984
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pubmed:articleTitle |
Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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