Linked Life Data

6437467

Source:http://linkedlifedata.com/resource/pubmed/id/6437467

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1984-12-24
pubmed:abstractText
The prophylactic effect of a semisynthetic heparin analogue (SSHA) on deep vein thrombosis was investigated in a prospective double-blind multicentre trial. 440 major general surgical and gynaecological patients were randomized to one of three treatment groups: 50 mg SSHA, 37.5 mg SSHA and 5000 units sodium heparin subcutaneously 12-hourly. Deep venous thrombosis (DVT) was diagnosed with the fibrinogen uptake test and verified with phlebography. Bleeding complications and other side-effects were carefully monitored. There were no significant differences between the three treatment groups of patients in age, sex, type of operation or risk factors. A DVT was diagnosed in 16 patients (12 per cent) in the SSHA 50 mg group, in 21 patients (15 per cent) in the SSHA 37.5 mg group and 21 patients (14 per cent) in the heparin-treated group. No significant differences were found in the number of patients who bled unexpectedly in the postoperative period, required transfusion or developed wound haematomas. Blood loss at operation was similar in all three groups. Three pulmonary emboli were diagnosed by pulmonary scintigraphy, one in each group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-1323
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
817-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:6437467-Adult, pubmed-meshheading:6437467-Aged, pubmed-meshheading:6437467-Anticoagulants, pubmed-meshheading:6437467-Chondroitin, pubmed-meshheading:6437467-Chondroitin Sulfates, pubmed-meshheading:6437467-Double-Blind Method, pubmed-meshheading:6437467-Female, pubmed-meshheading:6437467-Hemorrhage, pubmed-meshheading:6437467-Heparin, pubmed-meshheading:6437467-Humans, pubmed-meshheading:6437467-Intraoperative Complications, pubmed-meshheading:6437467-Male, pubmed-meshheading:6437467-Middle Aged, pubmed-meshheading:6437467-Postoperative Complications, pubmed-meshheading:6437467-Prospective Studies, pubmed-meshheading:6437467-Random Allocation, pubmed-meshheading:6437467-Risk, pubmed-meshheading:6437467-Surgical Procedures, Operative, pubmed-meshheading:6437467-Thrombophlebitis
pubmed:year
1984
pubmed:articleTitle
A randomized study of a semisynthetic heparin analogue and heparin in prophylaxis of deep vein thrombosis.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial