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pubmed:abstractText |
The biological clock of the female cycle is the ovary: the arise of estrogen primes the hypophysis for releasing hormones (GNRH) and cause the LH surge. Nevertheless, frequency and amplitude of GNRH are important points for the release of gonadotropic hormones and are involved in several pathophysiological situations: in corpus luteum insufficiency, in anovulation and in amenorrhoea.
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