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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1984-11-26
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pubmed:abstractText |
A reverse-phase HPLC system was used for the determination of inorganic chloride liberated in vivo from two biphenyl compounds in the rat. Oral administration of [4-36Cl]chlorobiphenyl resulted in a total yield of 27.6% of the original dose excreted over 10 d in the urine and included 1.7% of the dose as inorganic chloride. For [4,4'-36Cl]dichlorobiphenyl, the radioactivity of the original dose in the urine was 39.8% after 10 d, which included 11.5% of the dose as inorganic chloride. These results appear to represent the first direct determination of dechlorination by measurement of the inorganic chloride and suggest that biodechlorination plays a greater role in the metabolism of these compounds than previously expected.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3549
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-2
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
Direct chloride measurement of [4-36Cl]chlorobiphenyl and [4,4'-36Cl]dichlorobiphenyl dechlorination in the rat.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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