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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1984-12-18
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pubmed:abstractText |
Factor(s) in the supernatant of cultured mycoplasma arthritidis (MAS) represented potent inducers of interferon (IFN) in cultures of mouse spleen cells. Responding mouse strains included A/J, BALB/c, CBA, C3H, and DBA/2 whereas spleen cells of C57BL/6 and C57BL/10 mice were nonresponders. Interferon production was controlled by the I region of the H-2 locus. Treatment of CBA spleen cells by anti-thy-1 antibody plus C abolished IFN production. A similar effect was seen when CBA spleen cells were freed of macrophages by passage through Sephadex G-10 columns. Pure macrophages themselves, however, were not producing IFN when treated by MAS. Macrophage-depleted CBA spleen cells could be reconstituted to produce IFN by the addition of 2-ME. Interferon induction by CBA spleen cells was independent of lymphoproliferation as evidenced by experiments utilizing mitomycin C. The IFN induced by MAS represented IFN gamma (gamma), since it was acid-labile and neutralized by a specific antiserum.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0197-8357
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-97
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6436400-Animals,
pubmed-meshheading:6436400-Cells, Cultured,
pubmed-meshheading:6436400-Interferon-gamma,
pubmed-meshheading:6436400-Lymphocyte Activation,
pubmed-meshheading:6436400-Macrophages,
pubmed-meshheading:6436400-Male,
pubmed-meshheading:6436400-Mice,
pubmed-meshheading:6436400-Mice, Inbred Strains,
pubmed-meshheading:6436400-Mycoplasma,
pubmed-meshheading:6436400-Species Specificity,
pubmed-meshheading:6436400-Spleen
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pubmed:year |
1984
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pubmed:articleTitle |
Induction of interferon gamma in mouse spleen cells by culture supernatants of mycoplasma arthritidis.
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pubmed:publicationType |
Journal Article,
Comparative Study
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