Linked Life Data

6436180

Source:http://linkedlifedata.com/resource/pubmed/id/6436180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-12-14
pubmed:abstractText
A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-1-(m-trifluoromethyl)-phenyl-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was significantly reduced. Dexamethasone, a steroidal antiinflammatory agent, produced a delayed reduction. When administered at 2 h postcarrageenin, there was no effect at 3 h; but at 6 h, dexamethasone significantly reduced the swelling. In contrast, neither of the classic NSAs, aspirin or indomethacin, were effective when administered after the carrageenin. The results demonstrating a postcarrageenin effectiveness by BW 755C and dexamethasone are discussed as a possible reflection of an action on the lipoxygenase pathways of the arachidonic cascade that is not shared by the classic NSA.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0360-3997
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't