Linked Life Data

6436129

Source:http://linkedlifedata.com/resource/pubmed/id/6436129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-11-28
pubmed:abstractText
The effects on primary human skin fibroblasts of the structurally unrelated tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin B were compared with those of epidermal growth factor (EGF) and the non-promoting derivative 4-O-methyl TPA (4-O-MeTPA) by means of two-dimensional gel electrophoresis. Both TPA and teleocidin B caused a marked increase in the synthesis of two polypeptides with molecular weights of 44 kilodaltons (p44) and 55 kilodaltons (p55). P55 was complexed in cell lysates by antiactin antibody and was shown to be a component of the cytoskeleton. P44 migrated very near to actin, but was shown not to be a variant form of actin. No such specific increase in polypeptide synthesis was observed following treatment with either EGF or 4-O-MeTPA, suggesting that the increase in synthesis of p44 and p55 is specific to TPA and teleocidin, both agents with strong promoting activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0016-450X
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
672-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
A comparison of the effects of tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin on gene expression in human skin cell fibroblasts.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't