Linked Life Data

6435998

Source:http://linkedlifedata.com/resource/pubmed/id/6435998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-12-11
pubmed:abstractText
Effects of a single dose of 0.25 mg triazolam p.o. on saccadic eye movements were studied in 6 healthy volunteers. Triazolam was chosen because of its short half-life of 2.5 hours. Peak velocity, duration, acceleration/deceleration index, ratio of hypometric saccades and number of corrective saccades were measured before and at repeated intervals after triazolam administration over a period of 9 hours. Maximal change compared with baseline was observed 90 min. after drug administration. After 9 hours baseline values were reached. As with other benzodiazepines, peak velocity and duration of saccades were the most reliable parameters. Additionally, the number of corrective saccades was found to be a sensitive indicator of drug-induced impairment of oculomotor performance. The present study again emphasises the importance of saccadic eye movements for assessing effects of sedative drugs.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-7590
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-50
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
[Saccadic eye movements as a measure of the pharmacodynamics of benzodiazepines. Evaluation of various occulographic parameters].
pubmed:publicationType
Journal Article, English Abstract