Linked Life Data

64348

Source:http://linkedlifedata.com/resource/pubmed/id/64348

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-3-21
pubmed:abstractText
Selective repletion of 5-HT and catecholamines in the reserpinized cat was used to study the role of these biogenic amines in the regulation of PGO wave activity and sleep. The results include: 1. Repletion of 5-HT, following injections of D, L and L-5-HTP, suppressed PGORes in the pons and visual system. A consistent relationship between drug dose and duration of suppression was established. D-5-HTP failed to influence PGORes. L and D, L-5-HTP also induced a state closely resembling slow wave sleep and this change corresponded, temporally, with the period of wave suppression. 2. Repletion of catecholamined, following injections of L-DOPA, often caused behavioral arousal and a conversion from PGORes to PGOW. The molar dose of L-DOPA required to block PGORes was 10-20 times greater than that of L-5-HTP required for a comparable effect. In some cases, L-DOPA failed to arouse the cat, and in each of these instances, it failed to suppress PGORes. 3. L-DOPA consistently failed to induce a premature return of REM sleep in the reserpinized animal. These results suggest that 2 neuronal systems, one employing 5-HT and the other catecholamines, play a part in the regulation of PGORes, and presumably, PGOrem. The 5-HT system may be primarily responsible for suppressing PGOrem during slow wave sleep, with the catecholamine system playing a comparable part during wakefulness. Earlier reports that L-DOPA induces REM sleep in the reserpinized animal were not confirmed, indicating that the postulated role of catecholamines in the induction of this state should be reevaluated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-47
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Amine repletion in the reserpinized cat: effect upon PGO waves and REM sleep.
pubmed:publicationType
Journal Article