rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
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pubmed:dateCreated |
1984-11-20
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pubmed:abstractText |
In the rare familial disorder fish-eye disease, hypertriglyceridaemia is associated with elevated levels of very-low-density lipoprotein (VLDL) and enrichment of low-density lipoprotein (LDL) with triglyceride. The kinetic basis of the dyslipoproteinaemia was investigated by studying the metabolism of the apolipoprotein-B moeity of VLDL, intermediate-density lipoprotein (IDL) and LDL in a 68-year-old woman with this condition. The major kinetic abnormality was a pronounced reduction in the rate of fractional conversion of VLDL-B to IDL-B and of IDL-B to LDL-B, suggesting that the dyslipoproteinaemia represents accumulation in plasma of partly degraded products of VLDL metabolism. This kinetic disorder has features in common with type-III hyperlipoproteinaemia. In studies in vitro no defect in the enzyme, activator or substrate components of the lipoprotein lipase or hepatic lipase systems was observed.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, IDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2972
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6434321-Aged,
pubmed-meshheading:6434321-Cholesterol,
pubmed-meshheading:6434321-Cholesterol, HDL,
pubmed-meshheading:6434321-Cholesterol, LDL,
pubmed-meshheading:6434321-Eye Diseases,
pubmed-meshheading:6434321-Female,
pubmed-meshheading:6434321-Humans,
pubmed-meshheading:6434321-Hyperlipoproteinemia Type IV,
pubmed-meshheading:6434321-Kinetics,
pubmed-meshheading:6434321-Lipoproteins,
pubmed-meshheading:6434321-Lipoproteins, IDL,
pubmed-meshheading:6434321-Lipoproteins, VLDL,
pubmed-meshheading:6434321-Middle Aged,
pubmed-meshheading:6434321-Triglycerides
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pubmed:year |
1984
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pubmed:articleTitle |
Studies of lipoprotein metabolism in a patient with fish-eye disease.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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