Linked Life Data

6432903

Source:http://linkedlifedata.com/resource/pubmed/id/6432903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-10-15
pubmed:abstractText
Monoclonal antibodies (mAb) against cell surface structures have been used to identify several molecules involved in the interaction of human cytolytic T lymphocytes (CTL) with lymphoid and other bone marrow-derived targets. In allograft rejection or in graft-vs-host disease, however, major cellular targets are vascular and stromal cells, especially endothelium. Yet little is known about whether the same cell surface molecules are involved in the interactions of CTL with these cell types. We assessed the ability of mAb against effector or target cell structures to inhibit cytolysis of susceptible, cultured human vascular endothelium or dermal fibroblasts by a cloned human CTL line. Using mAb reactive with T3, T4, LFA-1, LFA-2, LFA-3, and HLA-DR, we found a qualitatively similar but quantitatively different pattern of inhibition of cytolysis as previously established for lymphoid targets by using the same CTL clone. These results have two implications: 1) the target cell structures recognized by CTL molecules such as T4, LFA-1 and LFA-2 are present on diverse cell types; and 2) the relative importance of such interactions may vary with target cell type. Furthermore, our studies provide several insights into the mechanisms of the interacting molecules. Our model system, and the use of pathophysiologically important target cells, may be useful for further analysis of CTL-mediated immune injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1878-84
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:6432903-Antibodies, Monoclonal, pubmed-meshheading:6432903-Antigens, Surface, pubmed-meshheading:6432903-Binding Sites, Antibody, pubmed-meshheading:6432903-Cell Communication, pubmed-meshheading:6432903-Cytotoxicity, Immunologic, pubmed-meshheading:6432903-Endothelium, pubmed-meshheading:6432903-Fibroblasts, pubmed-meshheading:6432903-HLA-DR Antigens, pubmed-meshheading:6432903-Histocompatibility Antigens Class II, pubmed-meshheading:6432903-Humans, pubmed-meshheading:6432903-Indium, pubmed-meshheading:6432903-Interferon-gamma, pubmed-meshheading:6432903-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:6432903-Radioisotopes, pubmed-meshheading:6432903-T-Lymphocytes, pubmed-meshheading:6432903-T-Lymphocytes, Cytotoxic, pubmed-meshheading:6432903-Umbilical Veins
pubmed:year
1984
pubmed:articleTitle
Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't