Linked Life Data

6431857

Source:http://linkedlifedata.com/resource/pubmed/id/6431857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-9-5
pubmed:abstractText
Disagreement exists on the effect of sleep on hypoxic ventilatory responses. We hypothesized that these differences were due to variabilities in methodology of inducing hypoxia, specifically, as they pertained to the PCO2 level during the studies. We therefore measured ventilatory responses to hypoxia with (eucapnic) and without (hypocapnic) added CO2 during wakefulness and sleep in 7 goats. Eucapnic responses to hypoxia were significantly decreased during both slow wave (SWS) and REM sleep. This decrease was not apparent when hypocapnia was allowed to occur. In 4 goats also provided with electromagnetic flow probes for brain blood flow (BBF) measurements, hypocapnia significantly attenuated the increase in BBF induced by hypoxia during both the awake and SWS stages. Concomitantly measured cerebral venous blood also showed lower oxygen tension during hypocapnia. We postulate that under hypocapnic conditions, the depressant effects of brain hypoxia may contribute to the obscuring of differences in hypoxic responses during wakefulness and sleep.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Determinants of the ventilatory responses to hypoxia during sleep.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.