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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1984-9-20
|
| pubmed:abstractText |
In a double-blind, cross-over study we measured the effect of a 0.5-mg oral dose of brotizolam, a new thienodiazepine hypnotic, on cardiac and respiratory functions in 12 healthy volunteers. No deleterious effects on pulse, blood pressure, forced vital capacity, forced expiratory volume in 1 s, respiratory rate, mouth occlusion pressure (P0.1) and ventilatory responses to carbon dioxide occurred over a 6-hour period. In the usual therapeutic dose, brotizolam does not suppress cardiac and respiratory functions in healthy volunteers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0025-7931
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
281-5
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading |
pubmed-meshheading:6431573-Adult,
pubmed-meshheading:6431573-Azepines,
pubmed-meshheading:6431573-Blood Pressure,
pubmed-meshheading:6431573-Carbon Dioxide,
pubmed-meshheading:6431573-Chemoreceptor Cells,
pubmed-meshheading:6431573-Forced Expiratory Volume,
pubmed-meshheading:6431573-Heart Rate,
pubmed-meshheading:6431573-Humans,
pubmed-meshheading:6431573-Hypnotics and Sedatives,
pubmed-meshheading:6431573-Male,
pubmed-meshheading:6431573-Respiration,
pubmed-meshheading:6431573-Respiratory Center,
pubmed-meshheading:6431573-Vital Capacity
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
The effects of brotizolam, a new hypnotic, on cardiac and respiratory function in volunteers.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|