Linked Life Data

6431122

Source:http://linkedlifedata.com/resource/pubmed/id/6431122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-9-14
pubmed:abstractText
Free fatty acid (FFA) and energy metabolism were studied in six severely burned humans after an 8-hr fast, after 1 hr of total parenteral nutrition, and after 72 hr of uninterrupted total parenteral nutrition. Caloric intake was twice the predicted basal metabolic rate, with 5 mg kg-1 min-1 of glucose, 2.5 g kg-1 day-1 of amino acid and the remainder of calories supplied as a fat emulsion. 1,2-13C-palmitate bound to albumin was continuously infused in order to quantitate FFA turnover and oxidation. Endogenous FFA turnover and oxidation were markedly suppressed by parenteral feeding, presumably due to increased insulin release. A modest recovery occurred in the initial suppression of FFA oxidation after 72 hr, but not in FFA turnover. Fat emulsion provided about one-quarter of the energy released during parenteral feeding, with endogenous FFA oxidation as the major component. This was roughly equivalent to the percentage of calories supplied as fat. This work indicates that the direct oxidation of a lipid emulsion contributes only a small amount of energy released in the setting of the severely traumatized human receiving total parenteral nutrition but serves mainly to preserve endogenous fat stores.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-6071
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-60
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Effect of total parenteral nutrition on free fatty acid metabolism in burned patients.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't