Linked Life Data

6430305

Source:http://linkedlifedata.com/resource/pubmed/id/6430305

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-8-1
pubmed:abstractText
This study was performed to evaluate the cardiac and haemodynamic effects of 1-cinnamyl-4-[bis(p-fluorophenyl)methyl]piperazine dihydrochloride (flunarizine, Sibelium ). The compound was dissolved in distilled water acidified with tartaric acid in a concentration of 2 mg/ml (pH 1.8) and administered intravenously in cumulative doses of 0.03, 0.1, 0.3, 1.0, and 3.0 mg/kg. Flunarizine induced systemic vasodilatation dose- relatedly starting with a dose of 0.1 mg/kg i.v. as indicated by the decrease in systemic vascular resistance, while this compound had no vasodilating properties in the pulmonary circulation. Flunarizine caused an increase in heart rate following the administration of the higher doses. This effect is probably reflexogenic in nature and secondary to the decrease in aortic blood pressure. As a consequence the oxygen demand of the myocardium enhanced after these high doses of flunarizine as indicated by the increase in pressure-rate product. Flunarizine did not affect the contractility and the conduction of the heart in the doses of 0.03 up to and including 1.0 mg/kg i.v., but could have some negative inotropic properties at the highest dose used. The end-tidal CO2 concentration in the expired air increased after the administration of 0.3 up to and including 3.0 mg/kg i.v. From these results, it is concluded that flunarizine has systemic vasodilating properties without any cardiac effects at doses from 0.03 up to and including 1.0 mg/kg i.v.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
434-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Cardiac and haemodynamic effects of intravenous administrations of flunarizine in closed-chest anaesthetized mongrel dogs.
pubmed:publicationType
Journal Article