Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-8-8
pubmed:abstractText
2-Difluoromethylornithine totally prevented any increases in putrescine and spermidine concentrations in the ventral prostate of castrated rats during a 6-day testosterone treatment. Prostatic ornithine decarboxylase activity was inhibited by 80%, whereas S-adenosylmethionine decarboxylase was stimulated by more than 9-fold. In seminal vesicle, the inhibition of putrescine and spermidine accumulation, as well as of ornithine decarboxylase activity, was only minimal, and no stimulation of S-adenosylmethionine decarboxylase was observed. Administration of methylglyoxal bis(guanylhydrazone) to castrated androgen-treated rats resulted in a marked increase in concentrations of all prostatic polyamines. Prostatic ornithine decarboxylase activity was nearly 2 times and adenosylmethionine decarboxylase activity 9 times higher than that of the testosterone-treated animals. In contrast with ventral prostate, methylglyoxal bis(guanylhydrazone) treatment inhibited moderately the accumulation of spermidine and spermine in seminal vesicle, although both ornithine decarboxylase and S-adenosylmethionine decarboxylase activities were stimulated. Difluoromethylornithine inhibited significantly the weight gain of ventral prostate, but methylglyoxal bis(guanylhydrazone) produced a substantial increase in prostatic weight. These changes were largely due to the fact that the volume of prostatic secretion was greatly decreased by difluoromethylornithine, whereas methylglyoxal bis(guanylhydrazone) increased the amount of secretion. Treatment with difluoromethylornithine strikingly increased the methylglyoxal bis(guanylhydrazone) content of both ventral prostate and seminal vesicle, but even under these conditions the drug concentration remained low in comparison with other tissues. The results indicate that a combined use of these two polyamine anti-metabolites does not necessarily result in a synergistic growth inhibition of the androgen-induced growth of male accessory sexual glands.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-13740357, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-14070391, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-14334364, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-431333, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-4550082, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-4764340, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-486129, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-4889860, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-4913442, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-5420953, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-5545514, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-5547701, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-606241, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6177318, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6401860, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6402294, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6403786, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6409968, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6766881, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6786285, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6786360, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6795040, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6796528, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-6813433, http://linkedlifedata.com/resource/pubmed/commentcorrection/6430275-7305912
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
219
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Differential effects of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the testosterone-induced growth of ventral prostate and seminal vesicles of castrated rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't