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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1984-8-20
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pubmed:abstractText |
Previous studies have demonstrated in vivo that T cells can provide protective immunity, in the absence of antibody, against infection with the extracellular Gram-negative bacterium Immunotype 1 (IT-1) Pseudomonas aeruginosa. We established an in vitro system in which immune T cells, after reexposure to bacterial antigens and to macrophages, secrete a product that kills the bacteria. Although macrophages are required for in vitro killing, they function neither as antigen-presenting nor as phagocytic cells in this system. T cells from animals immunized against a different P. aeruginosa immunotype will not kill IT-1 organisms; but the supernatants produced by IT-1 immune T cells after exposure to macrophages and IT-1 P. aeruginosa organisms are nonspecifically effective in killing unrelated bacteria. Because the supernatants from immune T cells lose their bactericidal properties upon minimal dilution, we conclude that if this mechanism is active in vivo, it must play a role in local immunity.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
962-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6429246-Animals,
pubmed-meshheading:6429246-B-Lymphocytes,
pubmed-meshheading:6429246-Cytotoxicity, Immunologic,
pubmed-meshheading:6429246-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6429246-Immunity, Cellular,
pubmed-meshheading:6429246-Lymphokines,
pubmed-meshheading:6429246-Macrophages,
pubmed-meshheading:6429246-Mice,
pubmed-meshheading:6429246-Mice, Inbred BALB C,
pubmed-meshheading:6429246-Polysaccharides, Bacterial,
pubmed-meshheading:6429246-Pseudomonas aeruginosa,
pubmed-meshheading:6429246-T-Lymphocytes,
pubmed-meshheading:6429246-Vinblastine
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pubmed:year |
1984
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pubmed:articleTitle |
In vitro T cell-mediated killing of Pseudomonas aeruginosa. I. Evidence that a lymphokine mediates killing.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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