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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024432,
umls-concept:C0027651,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0087111,
umls-concept:C0205307,
umls-concept:C0205373,
umls-concept:C0521009,
umls-concept:C0542341,
umls-concept:C1280500,
umls-concept:C1514468,
umls-concept:C1527392,
umls-concept:C1749467
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pubmed:issue |
1
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pubmed:dateCreated |
1984-8-7
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pubmed:abstractText |
The phagocytic and chemotactic activities of normal rat peritoneal macrophages were inhibited by sera from tumor-bearing rats (TBR) and 3 M KCl extracts of tumor mass. However, sera from Corynebacterium parvum- or Listeria monocytogenes-treated TBR did not inhibit phagocytosis. On the other hand, sera from C. parvum-treated, but not from L. monocytogenes-treated TBR still inhibited the chemotactic response of the normal macrophages. Furthermore, 3 M KCl extracts of tumors from C. parvum-treated TBR did not inhibit phagocytosis and chemotactic response of the same cells. Similar results were obtained with extracts of tumor masses from L. monocytogenes-treated rats. It is suggested that treatment with bacterial immunomodulators can influence the release from neoplastic cells of soluble products influencing normal macrophage functions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0340-7004
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-41
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6428737-Adjuvants, Immunologic,
pubmed-meshheading:6428737-Animals,
pubmed-meshheading:6428737-Chemotaxis,
pubmed-meshheading:6428737-Corynebacterium,
pubmed-meshheading:6428737-Female,
pubmed-meshheading:6428737-Humans,
pubmed-meshheading:6428737-Listeria monocytogenes,
pubmed-meshheading:6428737-Macrophages,
pubmed-meshheading:6428737-Male,
pubmed-meshheading:6428737-Neoplasms, Experimental,
pubmed-meshheading:6428737-Phagocytosis,
pubmed-meshheading:6428737-Rats
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pubmed:year |
1984
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pubmed:articleTitle |
Inhibition of normal rat macrophage functions by soluble tumor products. Effect of systemic treatment with bacterial immunomodulators.
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pubmed:publicationType |
Journal Article
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