Linked Life Data

6427866

Source:http://linkedlifedata.com/resource/pubmed/id/6427866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-7-25
pubmed:abstractText
The existing controversies on the pathogenesis of Chagas' heart disease can be simplified into two theories: (1) "neurogenic" which is concerned with the denervation of the ganglion cells of the heart (chiefly parasympathetic), theoretically resulting in a relative sympathetic overdrive to the heart, and (2) "immunoallergic", concerned with myocarditis, evoked by antibodies related to myocardial and/or parasite products. It is known that both patients and animals with Chagas' disease exhibit such serologic antibodies. Heart-specific antibodies are known to potentiate myocardial lesions caused by isoproterenol. This observation may provide clues in terms of a link between these two theories of the pathogenesis of Chagas' disease by virtue of two mutually potentiating mechanisms. To test the above hypothesis groups of control and T. cruzi-infected rats were submitted to either two s.c. injections of isoproterenol HCl (190 mg/kg) at 24 h intervals or saline solution. Ten days later, the survivors were killed, and gross heart lesions as well as a detailed histological grading of myocardial lesions were recorded. No differences were detected between control and T. cruzi-infected rats with respect to mortality, gross heart lesions, and myocardial histopathology after isoproterenol treatment. These results indicate no potentiation of myocardial lesions by isoproterenol in T. cruzi-infected rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9130
pubmed:author
pubmed:issnType
Print
pubmed:volume
184
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Non-potentiation of myocardial lesions by isoproterenol in T. cruzi-infected rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't