Linked Life Data

6426702

Source:http://linkedlifedata.com/resource/pubmed/id/6426702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-7-18
pubmed:abstractText
Monoclonal antibodies (MA) specific for neurofilaments (NF) and glial filaments (GF) were used to study the development of the normal human pituitary gland in fetuses, premature infants and adults. A total of 16 serially sectioned pituitary glands was examined. The expression of both NF and GF proteins correlated with maturation of the pituitary gland. Axons, but not cell bodies, were observed to contain immunoreactive NF proteins and these labeled axons were restricted almost exclusively to the pars nervosa. However, in early stages of development, intra-axonal NF proteins were not detectable. Aggregates of NF material in ' blobs ' were also observed in the pars nervosa of adults and a premature infant who survived 6 months following birth. They were never observed in more immature pituitary glands. Cells containing immunoreactive GF proteins were present in all subdivisions of the pituitary gland and they were more common in later stages of development. However, such cells represented only a minority of those present in the pituitary gland and cells in the pars distalis did not express GF protein until after birth. ' Blobs ' comprised of immunoreactive GF proteins were also seen. They were restricted to the pars nervosa and appeared later in development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:volume
315
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-39
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The developmental expression of neurofilament and glial filament proteins in the human pituitary gland: an immunohistochemical study with monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't